In this particular lesson, students are to develop and use a paper model to describe how structural changes to genes (mutations) may affect proteins and may result in harmful, beneficial, or neutral affects to the structure and function of an organism. Mutations Lesson Plans. Cancer Ras Gene Research: Lesson Plan (PDF) Lesson Plan (DOCX) with Membership. Experiment Students will do a BLAST and learn about how a mutated gene will code for a abnormal protein, affecting the organism’s phenotype. Exercise 5 - Nasal mutation practise (Lessons 8, 9 & 10) You will often find yourself needing to use this, so it's good to get in the habit of practicing it. This is also some further plural practice for you, as remember that when we're using 'in' it means there's more than one of whatever we're talking about!
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Apr 30, 2019 Students perform an activity similar to the childhood “telephone” game in which each communication step represents a biological process related to the passage of DNA from one cell to another. This game tangibly illustrates how DNA mutations can happen over several cell generations and the effects the mutations can have on the proteins that cells need to produce.
This activity uses a simulation from the Concord Consortium that shows how DNA is transcribed to RNA and then turned into a protein. It’s a very clear animation and can be used on its own as part of a lecture on protein synthesis.
The simulation then allows you to edit the DNA which will then create a new protein. The worksheet asks students to review terms and label an image showing tRNA, mRNA, codons, amino acids, and ribosomes.
Students then edit the DNA in a specific way so that they can observe the effects of a point mutation, a frameshift mutation, and a silent mutation. In the point mutation, a single base is changed which leads to a difference amino acid. Students do not need a codon chart to complete this activity.
You can also do this activity with the class if you have a projector, this would also allow more discussion on why some point mutations change the output protein and why some are silent.
Grade Level: 10-12
Time Required: 15-20 minutes
HS-LS1-1 Construct an explanation based on evidence for howthe structure of DNA determinesthe structure of proteins which carry out the essential functionsof life through systems of specialized cells
HS-LS3-1 Ask questions to clarify relationships aboutthe role of DNA and chromosomes in codingthe instructions for characteristic traits passed from parents to offspring.